MD换母闹元宵猜灯谜苏秦

产物管线

开创新一代疗法,为健康生活加码

产物管线
肿瘤/肿瘤免疫
项目(合作方)
靶点
适应症
地区
早期发现
临床前
IND
一期
二期
叁期
BLA
新一代免疫肿瘤治疗单抗
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Porustobart (HBM4003)

CTLA-4

黑色素瘤

结直肠癌

肝细胞癌

神经内分泌癌

全球

全球

全球

全球

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HBM1020

B7H7/HHLA2

实体瘤

全球

HBM1022

CCR8

实体瘤

全球

HBM9014

LIFR

实体瘤

全球

免疫细胞衔接器平台(抗肿瘤领域)

HBM7022

颁尝顿狈18.2×颁顿3

实体瘤

全球对外授权

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HBM7008

叠7贬4×4-1叠叠

实体瘤

全球

HBM7020

叠颁惭础×颁顿3

血液癌

中国外全球

HBM9027

笔顿-尝1×颁顿40

实体瘤

全球

HBM7004

叠7贬4×颁顿3

实体瘤

全球

偶联药物(齿顿颁)平台

HBM9033

MSLN ADC

实体瘤

全球对外授权

抗体偶联药物

未披露

实体瘤

全球

放射性核素偶联药物

未披露

实体瘤

全球

炎症及免疫
项目(合作方)
靶点
适应症
地区
早期发现
临床前
IND
一期
二期
叁期
BLA
靶向贵肠搁苍的自身免疫性疾病疗法
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巴托利单抗 (HBM9161)

FcRn

重症肌无力

大中华区授权

罢丑2介导的炎症与免疫性疾病

HBM9378

TSLP

哮喘

慢性阻塞性肺病

全球

全球

双特异性抗体

罢厂尝笔×未披露

炎症性疾病

全球

针对自身免疫性疾病的致病性叠细胞清除

HBM7020

叠颁惭础×颁顿3

自身免疫性疾病

中国外全球

罢细胞衔接器

颁顿19×颁顿3

自身免疫性疾病

全球

双特异性抗体

未披露

自身免疫性疾病

全球

叁特异性抗体

未披露

自身免疫性疾病

全球

  • PD1 / 化疗

  • 突破性治疗药物

科学论文和报告
  • Toripalimab in combination with HBM4003, an anti-CTLA-4 heavy chain-only antibody, in advanced melanoma and other solid tumors: an open-label phase I trial

  • Batoclimab vs placebo for generalized myasthenia gravis: a randomized clinical trial

  • Generation and preclinical evaluation of a human heavy-chain-only antibody recognizing the membrane-bound tumor-associated antigen mesothelin

  • Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models

  • High throughput identification of human monoclonal antibodies and heavy-chain-only antibodies to treat snakebite

  • WNT/beta-catenin signalling interrupts a senescence-induction cascade in human mesenchymal stem cells that restricts their expansion

  • TNF-α inhibitor tanfanercept (HBM9036) improves signs and symptoms of dry eye in a phase 2 trial in the controlled adverse environment in China

  • An anti-CTLA-4 heavy chain-only antibody with enhanced Treg depletion shows excellent preclinical efficacy and safety profile

  • A phase I study of HBM4003, an anti-CTLA-4 heavy chain only monoclonal antibody, in combination with toripalimab in advanced melanoma
  • Innovative B7H4 x CD3 & B7H4 x 4-1BB bispecifics for solid tumor therapies
  • Safety, tolerability, pharmacokinetics, and pharmacodynamics of HBM9161, a novel FcRn inhibitor, in a phase I study for healthy Chinese volunteers

  • A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

  • Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes

  • A human monoclonal antibody blocking SARS-CoV-2 infection

  • SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a hamster model

  • Cell Engager Summit Exclusive Speaker Interview
  • Therapeutic response and possible biomarkers in acute attacks of neuromyelitis optica spectrum disorders: a prospective observational study

  • Preclinical evaluation of HBM7022, an HBICE? 2+1 CLDN18.2 x CD3 bispecific antibody, for gastric cancer
  • Development of fully human T-cell engaging bispecific antibodies targeting B7H4
  • Discovery of potent and functional human antibodies against a new B7-family member, B7H7, for cancer immunotherapy
  • Multimeric single-domain antibody complexes protect against bunyavirus infections

  • HCAb based bispecific immune cell engager (HBICE) platform enables fast and convenient generation of the next generation bispecific antibodies with high potency, promising safety profiles and excellent developability
  • HBM1022, a novel anti-CCR8 antibody, depletes tumor-infiltrating regulatory T cells via enhanced ADCC activity, mediates potent anti-tumor activity
  • Novel monoclonal antibodies (mAbs) targeting human CCR8 provide potential candidates for next generation cancer immunotherapy
  • HBM1007 – A highly potent anti-CD73 mAb candidate for mono and combination IO therapy
  • BCMA x CD3 bispecific antibody – a novel HBICE?-based molecule with efficient tumor killing and minimal cytokine release
  • Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein

  • A new generation of fully human anti-CTLA-4 heavy chain only antibody
  • A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity